Fri Feb 21 2025

20 articles - From Friday Feb 14 2025 to Friday Feb 21 2025

parm_toc.knit

Guidelines

Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…


Meta-analysis

meta-analyses and systematic reviews

J Crohns Colitis

Systematic review: severe endoscopic lesions in inflammatory bowel disease.

There is currently no validated definition of SEL in IBD. When present, they are associated with steroid failure in the setting of ASUC, but do not affect response to anti-TNF in either CD or ASUC.

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Original articles

RCT, clinical trials, retrospective studies, etc…

Am J Clin Nutr

Associations between flavonoid-rich food and flavonoid intakes and incident unhealthy aging outcomes in older U.S. males and females.

High intakes of flavonoid-rich foods may support healthy aging. Further research is needed, including examining sex-specific associations, as incorporating flavonoid-rich foods in the diet may be a simple strategy to support healthy aging.

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Choline enhances elicited imitation memory performance in pre-school children with prenatal alcohol exposure: A cumulative report of three randomized controlled trials.

The results support choline as a neurodevelopmental intervention for improvement of memory in young children exposed to alcohol prenatally. Specifically, the use of choline bitartrate as a supplement in the range of 260 to 500 mg per day in children between 2.5 and 5.9 years of age is supported. Future studies are needed to further define appropriate dosage as well as optimal lengths and developmental windows for supplementation. Clinical trial registration

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Differential Association of Ultra-processed Food Categories with Risk of Developing Cognitive Impairment in Middle-Aged and Older Adults in a Longitudinal Panel Study.

These results reinforce the value of separating UPF into categories. The link between UPF animal products and beverages with cognitive functions may be, in part, explained by their ingredients, such as additives, or by the poor nutritional composition of prducts rich in simple sugars and low in dietary fibers.

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Effect of kangaroo mother care in low birth weight infants on human milk intake: a randomized controlled trial.

Our findings show that KMC is associated with a substantially higher human milk intake in LBW infants during the neonatal period. There were no evidence of any effect of KMC on the concentration of several human milk components. Clinical trial registry number and website where it was obtained CTRI/2017/04/008430, Clinical Trials Registry - India.

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Standard reference for daily urinary creatinine excretion among individuals with obesity: a monocentric, retrospective, observational study.

Daily urinary creatinine excretion is significantly higher among individuals with obesity than in healthy weight population. We propose new standard reference for urinary creatinine excretion in individuals with obesity.

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Inflamm Bowel Dis

Deep Sequencing of Crohn's Disease Lamina Propria Phagocytes Identifies Pathobionts and Correlates With Pro-Inflammatory Gene Expression.

Lamina propria resident phagocytes harbor bacterial strains that may act as pathobionts in CD. Our findings shed light on the role of pathobionts and the immune response in CD pathogenesis and suggest new targets for therapies.

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Mitochondrial Dysfunction: Unraveling the Elusive Biology Behind Anti-TNF Response During Ulcerative Colitis.

Our results highlight the involvement of metabolic pathways and mitochondrial homeostasis in determining treatment response and their ability to provide promising classification signals with detection levels in both the colon and the bloodstream.

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NHE3 Controls Proliferation and Migration of Colonic Epithelial Cells.

Inhibition of NHE3, unconfounded by chronic inflammatory or microbial pressure, may represent a permissible mechanism beneficial to the host by modulating cellular plasticity and promoting epithelial wound healing. These unexpected results provide a novel insight into the pleiotropic roles of NHE3 in mucosal homeostasis.

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S1P Lyase Inhibition Increased Intestinal S1P, Disrupted the Intestinal Barrier and Aggravated DSS-Induced Colitis.

Homeostatic intestinal S1P levels are critical for the regulation of IEC barrier function. Further studies using adaptive immunity-based inflammatory bowel diseases (IBD) models are required to assess the translational value of IEC-specific SPL inhibition as a therapeutic target for human IBD.

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J Crohns Colitis

A transcriptomic score to classify the inflammation-dysplasia-cancer sequence lesions in Inflammatory Bowel Disease.

We identified a tissue-based transcriptomic score to classify IDC lesions in IBD patients and uncovered some of the pivotal genes in the carcinogenesis related to inflammation in IBD.

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Prevalence, incidence and mortality of inflammatory bowel disease in the Netherlands: development and external validation of machine learning models.

IBD cases can be accurately identified using administrative data. The prevalence of IBD in the Netherlands is increasing slower than expected, suggesting a trend towards the epidemiological stage of Prevalence Equilibrium.

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The ulcerative colitis risk gene adenylyl cyclase 7 restrains the T helper 2 phenotype and Class II antigen presentation.

The ulcerative colitis risk-conferring variant, p.Asp439Glu, in ADCY7 reduces cyclic AMP signaling, leading to modifications in cytokine profile and antigen presentation. Medications that enhance cyclic AMP by direct activation of ADCY7 or by phosphodiesterase inhibition may be beneficial in this disease.

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Liver Transpl

Cannabis and liver transplant in the era of legalization: Effects of pre-transplant cannabis use on postoperative opioid use and transplant outcomes.

While cannabis use pre-LT was associated with significantly higher opioid use in the immediate postoperative period, this did not translate to differences in opioid use beyond 48 hours post-LT, or short-term healthcare utilization or clinical outcomes. These findings should help set provider expectations for immediate post-LT pain control. Our findings support the growing body of literature that fails to identify an association between pre-LT cannabis use and post-LT outcomes.

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Co-producing a health advocate intervention for pediatric liver transplant recipients using human-centered design.

Using structured design methodology, we designed a prototype navigator role for pediatric liver transplant care teams. Future studies should test the effectiveness of this navigator role in improving post-transplant outcomes.

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Lower child opportunity index is associated with increased healthcare utilization following pediatric liver transplantation.

We also observed that in the second year post-LT, children with a lower COI were more often admitted with a complication of LT (23%) than those with a higher COI (18%). COI may be a useful composite screening instrument for clinical teams to target resources and limit acute care use post-LT.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link


Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Inflamm Bowel Dis

Upadacitinib in Autoimmune Enteropathy-A Case Report.

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J Crohns Colitis

Correction to: Volume 19, Supplement 1.

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Pancreas

Protocol and Study Population of a Prospective Study of Patients With Chronic Pancreatitis and Exocrine Pancreatic Insufficiency: Preliminary Findings From the PACT-CP Registry Show Reduced Health-Related Quality of Life.

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Letters&Replies

Letters to the editors and authors’ replies

Pancreatology

Letter to the editor: Risk score to predict inpatient mortality of acute pancreatitis patients admitted to the intensive care unit.

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